Pregabalin for the management of partial epilepsy
نویسندگان
چکیده
منابع مشابه
Pregabalin for the management of partial epilepsy
Pregabalin is one of the latest antiepileptic drugs introduced for the treatment of partial epilepsy. Its efficacy and safety as adjunctive therapy in refractory partial epilepsy have been established in four double-blind placebo-controlled trials (n = 1396) and 4 long-term open-label studies (n = 1480). In 3 fixed-dose trials, the proportion of patients with a >/=50% reduction in seizure frequ...
متن کاملPregabalin in the management of partial epilepsy
Pregabalin is a new antiepileptic medication that works by binding to alpha 2 delta subunit of the voltage-dependent calcium channels present in presynaptic neurons. Its pharmacokinetic advantages include rapid and almost complete absorption, lack of protein binding, linear kinetics, absence of enzyme induction, and absence of interactions with other drugs. Pregabalin was found effective as adj...
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ژورنال
عنوان ژورنال: Neuropsychiatric Disease and Treatment
سال: 2008
ISSN: 1176-6328
DOI: 10.2147/ndt.s4716